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Table 2 Changes in clinical results before the first HA injection (week 0) and fifth injection (week 5)

From: Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis

  Week 0 Week 5 Pvalue
Range of motion (degrees) 129 ± 13 140 ± 7 <0.001
AKSKS (points) 63.8 ± 10.8 80.0 ± 10.1 <0.001
AKSFS (points) 72.6 ± 11.8 92.7 ± 7.0 <0.001
KOOS Pain (points) 56.2 ± 17.5 81.3 ± 11.2 <0.001
KOOS Symptoms (points) 62.6 ± 14.8 82.4 ± 12.8 <0.001
KOOS Activity of Daily Living (points) 72.6 ± 17.4 90.3 ± 8.1 <0.001
KOOS Sports (points) 45.1 ± 18.6 73.9 ± 13.6 <0.001
KOOS Quality of Life (points) 35.5 ± 14.8 63.6 ± 16.3 <0.001
Total KOOS score 272.0 ± 73.7 391.6 ± 50.8 <0.001
  1. AKSKS: American Knee Society knee score. AKSFS: American Knee Society function score. KOOS: Knee injury and Osteoarthritis Outcome Score.
  2. Data are given as mean ± standard deviation.