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Table 3 Modified O’Driscoll Histology Score[13]

From: Osteochondral tissue engineering using a biphasic collagen/GAG scaffold containing rhFGF18 or BMP-7 in an ovine model

  Characteristic   Grading Score
I % Hyaline Cartilage:   80-100 8
    60-80 6
    40-60 4
    20-40 2
    0-20 0
II Structural A. Surface irregularity: Smooth and intact 2
  Characteristics:   Fissures 1
    Severe disruption, fibrillation 0
   B. Structural integrity: Normal 2
    Slight disruption, including cysts 1
    Severe lack of integration 0
   C. Thickness: 100% of normal adjacent cartilage 2
    50-100% or thicker than normal 1
    0-50% 0
   D. Bonding to adjacent cartilage: Bonded at both ends of graft 2
    Bonded at one end/partially both ends 1
    Not bonded 0
III Freedom from cellular changes of degeneration:   Normal cellularity, no clusters 2
    Slight hypocellularity, <25% chondrocyte clusters 1
    Moderate hypocellularity, >25% clusters 0
IV Freedom from degenerate changes in adjacent cartilage:   Normal cellularity, no clusters, normal staining 3
    Normal cellularity, mild clusters, moderate staining 2
    Mild or mod hypocellularity, slight staining 1
    Severe hypocellularity, slight staining 0
V Reconstitution of subchondral bone:   complete reconstitution 2
    greater than 50% reconstitution 1
    50% or less reconstitution 0
VI Bonding of repair cartilage to denovo subchondral bone:   complete and uninterrupted 2
    <100% but >50% recon 1
    <50% complete 0
VII Safranin O staining:   > 80% homogenous positive stain 2
    40-80% homogenous positive stain 1
    <40% homogenous positive stain 0
    TOTAL SCORE Max 27