Figure 8From: The role of aggrecan in normal and osteoarthritic cartilageProteolytic cleavage sites within the aggrecan core protein. The location of cleavage sites on the human aggrecan core protein determined in vitro by the action of proteases known to be active in cartilage in vivo are shown. A, ADAMTS4/5; C, calpain; H, HtrA1; M, MMPs.Back to article page