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Figure 6 | Journal of Experimental Orthopaedics

Figure 6

From: The role of aggrecan in normal and osteoarthritic cartilage

Figure 6

Mechanisms of proteoglycan aggregate degradation. A proteoglycan aggregate bearing five aggrecan molecules is depicted. Degradation is represented following proteolysis of the aggrecan core protein, non-enzymic glycation of the aggrecan core protein and link protein, and hyaluronidase or free radical cleavage of hyaluronan.

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