TY - JOUR AU - Antoniou, J. AU - Wang, H. T. AU - Alaseem, A. M. AU - Haglund, L. AU - Roughley, P. J. AU - Mwale, F. PY - 2012 DA - 2012// TI - The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells JO - Arthritis Res Ther VL - 14 UR - https://doi.org/10.1186/ar4113 DO - 10.1186/ar4113 ID - Antoniou2012 ER - TY - JOUR AU - Aspberg, A. PY - 2012 DA - 2012// TI - The different roles of aggrecan interaction domains JO - J Histochem Cytochem VL - 60 UR - https://doi.org/10.1369/0022155412464376 DO - 10.1369/0022155412464376 ID - Aspberg2012 ER - TY - JOUR AU - Balduini, C. AU - De, L. G. AU - Passi, A. AU - Rindi, S. AU - Salvini, R. AU - Scott, J. E. PY - 1992 DA - 1992// TI - Effect of oxygen tension and lactate concentration on keratan sulphate and chondroitin sulphate biosynthesis in bovine cornea JO - Biochim Biophys Acta VL - 1115 UR - https://doi.org/10.1016/0304-4165(92)90052-V DO - 10.1016/0304-4165(92)90052-V ID - Balduini1992 ER - TY - JOUR AU - Barry, F. P. AU - Neame, P. J. AU - Sasse, J. AU - Pearson, D. PY - 1994 DA - 1994// TI - Length variation in the keratan sulfate domain of mammalian aggrecan JO - Matrix Biol VL - 14 UR - https://doi.org/10.1016/0945-053X(94)90198-8 DO - 10.1016/0945-053X(94)90198-8 ID - Barry1994 ER - TY - JOUR AU - Barry, F. P. AU - Rosenberg, L. C. AU - Gaw, J. U. AU - Koob, T. J. AU - Neame, P. J. PY - 1995 DA - 1995// TI - N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage JO - J Biol Chem VL - 270 UR - https://doi.org/10.1074/jbc.270.35.20516 DO - 10.1074/jbc.270.35.20516 ID - Barry1995 ER - TY - JOUR AU - Brown, G. M. AU - Huckerby, T. N. AU - Bayliss, M. T. AU - Nieduszynski, I. A. PY - 1998 DA - 1998// TI - Human aggrecan keratan sulfate undergoes structural changes during adolescent development JO - J Biol Chem VL - 273 UR - https://doi.org/10.1074/jbc.273.41.26408 DO - 10.1074/jbc.273.41.26408 ID - Brown1998 ER - TY - JOUR AU - Camp, C. L. AU - Stuart, M. J. AU - Krych, A. J. PY - 2014 DA - 2014// TI - Current concepts of articular cartilage restoration techniques in the knee JO - Sports Health VL - 6 UR - https://doi.org/10.1177/1941738113508917 DO - 10.1177/1941738113508917 ID - Camp2014 ER - TY - JOUR AU - Campion, G. V. AU - McCrae, F. AU - Schnitzer, T. J. AU - Lenz, M. E. AU - Dieppe, P. A. AU - Thonar, E. J. PY - 1991 DA - 1991// TI - Levels of keratan sulfate in the serum and synovial fluid of patients with osteoarthritis of the knee JO - Arthritis Rheum VL - 34 UR - https://doi.org/10.1002/art.1780341008 DO - 10.1002/art.1780341008 ID - Campion1991 ER - TY - JOUR AU - Caterson, B. AU - Mahmoodian, F. AU - Sorrell, J. M. AU - Hardingham, T. E. AU - Bayliss, M. T. AU - Carney, S. L. AU - Ratcliffe, A. AU - Muir, H. PY - 1990 DA - 1990// TI - Modulation of native chondroitin sulfate structure in tissue development and in disease JO - J Cell Sci VL - 97 ID - Caterson1990 ER - TY - JOUR AU - Chamberland, A. AU - Wang, E. AU - Jones, A. R. AU - Collins-Racie, L. A. AU - LaVallie, E. R. AU - Huang, Y. AU - Liu, L. AU - Morris, E. A. AU - Flannery, C. R. AU - Yang, Z. PY - 2009 DA - 2009// TI - Identification of a novel HtrA1-susceptible cleavage site in human aggrecan JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M109.037051 DO - 10.1074/jbc.M109.037051 ID - Chamberland2009 ER - TY - JOUR AU - Clark, I. M. AU - Parker, A. E. PY - 2003 DA - 2003// TI - Metalloproteinases: their role in arthritis and potential as therapeutic targets JO - Expert Opin Ther Targets VL - 7 UR - https://doi.org/10.1517/14728222.7.1.19 DO - 10.1517/14728222.7.1.19 ID - Clark2003 ER - TY - JOUR AU - Cloos, P. A. AU - Christgau, S. PY - 2002 DA - 2002// TI - Non-enzymatic covalent modifications of proteins: mechanisms, physiological consequences and clinical applications JO - Matrix Biol VL - 21 UR - https://doi.org/10.1016/S0945-053X(01)00188-3 DO - 10.1016/S0945-053X(01)00188-3 ID - Cloos2002 ER - TY - JOUR AU - Csoka, A. B. AU - Frost, G. I. AU - Stern, R. PY - 2001 DA - 2001// TI - The six hyaluronidase-like genes in the human and mouse genomes JO - Matrix Biol VL - 20 UR - https://doi.org/10.1016/S0945-053X(01)00172-X DO - 10.1016/S0945-053X(01)00172-X ID - Csoka2001 ER - TY - JOUR AU - Dabiri, Y. AU - Li, L. P. PY - 2013 DA - 2013// TI - Influences of the depth-dependent material inhomogeneity of articular cartilage on the fluid pressurization in the human knee JO - Med Eng Phys VL - 35 UR - https://doi.org/10.1016/j.medengphy.2013.05.005 DO - 10.1016/j.medengphy.2013.05.005 ID - Dabiri2013 ER - TY - JOUR AU - Deng, H. AU - O'Keefe, H. AU - Davie, C. P. AU - Lind, K. E. AU - Acharya, R. A. AU - Franklin, G. J. AU - Larkin, J. AU - Matico, R. AU - Neeb, M. AU - Thompson, M. M. AU - Lohr, T. AU - Gross, J. W. AU - Centrella, P. A. AU - O'Donovan, G. K. AU - Bedard, K. L. AU - Van, V. K. AU - Mataruse, S. AU - Skinner, S. R. AU - Belyanskaya, S. L. AU - Carpenter, T. Y. AU - Shearer, T. W. AU - Clark, M. A. AU - Cuozzo, J. W. AU - Arico-Muendel, C. C. AU - Morgan, B. A. PY - 2012 DA - 2012// TI - Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT) JO - J Med Chem VL - 55 UR - https://doi.org/10.1021/jm300449x DO - 10.1021/jm300449x ID - Deng2012 ER - TY - JOUR AU - Doege, K. AU - Sasaki, M. AU - Horigan, E. AU - Hassell, J. R. AU - Yamada, Y. PY - 1987 DA - 1987// TI - Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones JO - J Biol Chem VL - 262 ID - Doege1987 ER - TY - JOUR AU - Doege, K. J. AU - Coulter, S. N. AU - Meek, L. M. AU - Maslen, K. AU - Wood, J. G. PY - 1997 DA - 1997// TI - A human-specific polymorphism in the coding region of the aggrecan gene: variable number of tandem repeats produce a range of core protein sizes in the general population JO - J Biol Chem VL - 272 UR - https://doi.org/10.1074/jbc.272.21.13974 DO - 10.1074/jbc.272.21.13974 ID - Doege1997 ER - TY - JOUR AU - Doege, K. J. AU - Sasaki, M. AU - Kimura, T. AU - Yamada, Y. PY - 1991 DA - 1991// TI - Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan: human-specific repeats, and additional alternatively spliced forms JO - J Biol Chem VL - 266 ID - Doege1991 ER - TY - JOUR AU - Dudhia, J. AU - Davidson, C. M. AU - Wells, T. M. AU - Hardingham, T. E. AU - Bayliss, M. T. PY - 1996 DA - 1996// TI - Studies on the G3 domain of aggrecan from human cartilage JO - Ann NY Acad Sci VL - 785 UR - https://doi.org/10.1111/j.1749-6632.1996.tb56273.x DO - 10.1111/j.1749-6632.1996.tb56273.x ID - Dudhia1996 ER - TY - JOUR AU - Dudhia, J. AU - Davidson, C. M. AU - Wells, T. M. AU - Vynios, D. H. AU - Hardingham, T. E. AU - Bayliss, M. T. PY - 1996 DA - 1996// TI - Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage JO - Biochem J VL - 313 UR - https://doi.org/10.1042/bj3130933 DO - 10.1042/bj3130933 ID - Dudhia1996 ER - TY - JOUR AU - Dufield, D. R. AU - Nemirovskiy, O. V. AU - Jennings, M. G. AU - Tortorella, M. D. AU - Malfait, A. M. AU - Mathews, W. R. PY - 2010 DA - 2010// TI - An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: use as a biomarker for aggrecanase activity and cartilage degradation JO - Anal Biochem VL - 406 UR - https://doi.org/10.1016/j.ab.2010.06.044 DO - 10.1016/j.ab.2010.06.044 ID - Dufield2010 ER - TY - JOUR AU - Eigenbrot, C. AU - Ultsch, M. AU - Lipari, M. T. AU - Moran, P. AU - Lin, S. J. AU - Ganesan, R. AU - Quan, C. AU - Tom, J. AU - Sandoval, W. AU - van Lookeren, C. M. AU - Kirchhofer, D. PY - 2012 DA - 2012// TI - Structural and functional analysis of HtrA1 and its subdomains JO - Structure VL - 20 UR - https://doi.org/10.1016/j.str.2012.03.021 DO - 10.1016/j.str.2012.03.021 ID - Eigenbrot2012 ER - TY - JOUR AU - Farndale, R. W. AU - Buttle, D. J. AU - Barrett, A. J. PY - 1986 DA - 1986// TI - Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue JO - Biochim Biophys Acta VL - 833 UR - https://doi.org/10.1016/0304-4165(86)90306-5 DO - 10.1016/0304-4165(86)90306-5 ID - Farndale1986 ER - TY - JOUR AU - Flannery, C. R. AU - Lark, M. W. AU - Sandy, J. D. PY - 1992 DA - 1992// TI - Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan: evidence for proteolysis at this site in vivo in human articular cartilage JO - J Biol Chem VL - 267 ID - Flannery1992 ER - TY - JOUR AU - Fosang, A. J. AU - Hardingham, T. E. PY - 1989 DA - 1989// TI - Isolation of the N-terminal globular domains from cartilage proteoglycan: identification of G2 domain and its lack of interaction with hyaluronate and link protein JO - Biochem J VL - 261 UR - https://doi.org/10.1042/bj2610801 DO - 10.1042/bj2610801 ID - Fosang1989 ER - TY - JOUR AU - Fosang, A. J. AU - Last, K. AU - Gardiner, P. AU - Jackson, D. C. AU - Brown, L. PY - 1995 DA - 1995// TI - Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluid JO - Biochem J VL - 310 UR - https://doi.org/10.1042/bj3100337 DO - 10.1042/bj3100337 ID - Fosang1995 ER - TY - JOUR AU - Fosang, A. J. AU - Neame, P. J. AU - Last, K. AU - Hardingham, T. E. AU - Murphy, G. AU - Hamilton, J. A. PY - 1992 DA - 1992// TI - The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B JO - J Biol Chem VL - 267 ID - Fosang1992 ER - TY - JOUR AU - Fosang, A. J. AU - Stanton, H. AU - Little, C. B. AU - Atley, L. M. PY - 2003 DA - 2003// TI - Neoepitopes as biomarkers of cartilage catabolism JO - Inflamm Res VL - 52 ID - Fosang2003 ER - TY - JOUR AU - Fraser, J. R. AU - Laurent, T. C. AU - Laurent, U. B. PY - 1997 DA - 1997// TI - Hyaluronan: its nature, distribution, functions and turnover JO - J Intern Med VL - 242 UR - https://doi.org/10.1046/j.1365-2796.1997.00170.x DO - 10.1046/j.1365-2796.1997.00170.x ID - Fraser1997 ER - TY - JOUR AU - Fülöp, C. AU - Cs-Szabó, G. AU - Glant, T. T. PY - 1996 DA - 1996// TI - Species-specific alternative splicing of the epidermal growth factor-like domain 1 of cartilage aggrecan JO - Biochem J VL - 319 UR - https://doi.org/10.1042/bj3190935 DO - 10.1042/bj3190935 ID - Fülöp1996 ER - TY - JOUR AU - Germaschewski, F. M. AU - Matheny, C. J. AU - Larkin, J. AU - Liu, F. AU - Thomas, L. R. AU - Saunders, J. S. AU - Sully, K. AU - Whittall, C. AU - Boyle, Y. AU - Peters, G. AU - Graham, N. M. PY - 2014 DA - 2014// TI - Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients JO - Osteoarthritis Cartilage VL - 22 UR - https://doi.org/10.1016/j.joca.2014.02.930 DO - 10.1016/j.joca.2014.02.930 ID - Germaschewski2014 ER - TY - JOUR AU - Gleghorn, J. P. AU - Jones, A. R. AU - Flannery, C. R. AU - Bonassar, L. J. PY - 2009 DA - 2009// TI - Boundary mode lubrication of articular cartilage by recombinant human lubricin JO - J Orthop Res VL - 27 UR - https://doi.org/10.1002/jor.20798 DO - 10.1002/jor.20798 ID - Gleghorn2009 ER - TY - JOUR AU - Goldring, S. R. AU - Goldring, M. B. PY - 2004 DA - 2004// TI - The role of cytokines in cartilage matrix degeneration in osteoarthritis JO - Clin Orthop Relat Res VL - 427 UR - https://doi.org/10.1097/01.blo.0000144854.66565.8f DO - 10.1097/01.blo.0000144854.66565.8f ID - Goldring2004 ER - TY - JOUR AU - Grau, S. AU - Richards, P. J. AU - Kerr, B. AU - Hughes, C. AU - Caterson, B. AU - Williams, A. S. AU - Junker, U. AU - Jones, S. A. AU - Clausen, T. AU - Ehrmann, M. PY - 2006 DA - 2006// TI - The role of human HtrA1 in arthritic disease JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M500361200 DO - 10.1074/jbc.M500361200 ID - Grau2006 ER - TY - JOUR AU - Grover, J. AU - Roughley, P. J. PY - 1993 DA - 1993// TI - Versican gene expression in human articular cartilage and comparison of mRNA splicing variation with aggrecan JO - Biochem J VL - 291 UR - https://doi.org/10.1042/bj2910361 DO - 10.1042/bj2910361 ID - Grover1993 ER - TY - JOUR AU - Gushulak, L. AU - Hemming, R. AU - Martin, D. AU - Seyrantepe, V. AU - Pshezhetsky, A. AU - Triggs-Raine, B. PY - 2012 DA - 2012// TI - Hyaluronidase 1 and β-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M112.350447 DO - 10.1074/jbc.M112.350447 ID - Gushulak2012 ER - TY - JOUR AU - Hascall, V. C. PY - 1988 DA - 1988// TI - Proteoglycans: the chondroitin sulfate/keratan sulfate proteoglycans of cartilage JO - ISI Atlas Sci Biochem VL - 1 ID - Hascall1988 ER - TY - JOUR AU - Hascall, V. C. AU - Heinegård, D. PY - 1974 DA - 1974// TI - Aggregation of cartilage proteoglycans: II: oligosaccharide competitors of the proteoglycan-hyaluronic acid interaction JO - J Biol Chem VL - 249 ID - Hascall1974 ER - TY - JOUR AU - Hering, T. M. AU - Kollar, J. AU - Huynh, T. D. PY - 1997 DA - 1997// TI - Complete coding sequence of bovine aggrecan: comparative structural analysis JO - Arch Biochem Biophys VL - 345 UR - https://doi.org/10.1006/abbi.1997.0261 DO - 10.1006/abbi.1997.0261 ID - Hering1997 ER - TY - JOUR AU - Holmes, M. W. A. AU - Bayliss, M. T. AU - Muir, H. PY - 1988 DA - 1988// TI - Hyaluronic acid in human articular cartilage: age-related changes in content and size JO - Biochem J VL - 250 UR - https://doi.org/10.1042/bj2500435 DO - 10.1042/bj2500435 ID - Holmes1988 ER - TY - JOUR AU - Hou, W. S. AU - Li, Z. AU - Büttner, F. H. AU - Bartnik, E. AU - Brömme, D. PY - 2003 DA - 2003// TI - Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation JO - Biol Chem VL - 384 UR - https://doi.org/10.1515/BC.2003.100 DO - 10.1515/BC.2003.100 ID - Hou2003 ER - TY - JOUR AU - Hubbard, C. AU - McNamara, J. T. AU - Azumaya, C. AU - Patel, M. S. AU - Zimmer, J. PY - 2012 DA - 2012// TI - The hyaluronan synthase catalyzes the synthesis and membrane translocation of hyaluronan JO - J Mol Biol VL - 418 UR - https://doi.org/10.1016/j.jmb.2012.01.053 DO - 10.1016/j.jmb.2012.01.053 ID - Hubbard2012 ER - TY - JOUR AU - Hughes, C. E. AU - Caterson, B. AU - Fosang, A. J. AU - Roughley, P. J. AU - Mort, J. S. PY - 1995 DA - 1995// TI - Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro JO - Biochem J VL - 305 UR - https://doi.org/10.1042/bj3050799 DO - 10.1042/bj3050799 ID - Hughes1995 ER - TY - JOUR AU - Itano, N. AU - Sawai, T. AU - Yoshida, M. AU - Lenas, P. AU - Yamada, Y. AU - Imagawa, M. AU - Shinomura, T. AU - Hamaguchi, M. AU - Yoshida, Y. AU - Ohnuki, Y. AU - Miyauchi, S. AU - Spicer, A. P. AU - McDonald, J. A. AU - Kimata, K. PY - 1999 DA - 1999// TI - Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties JO - J Biol Chem VL - 274 UR - https://doi.org/10.1074/jbc.274.35.25085 DO - 10.1074/jbc.274.35.25085 ID - Itano1999 ER - TY - JOUR AU - Knudson, C. B. AU - Nofal, G. A. AU - Pamintuan, L. AU - Aguiar, D. J. PY - 1999 DA - 1999// TI - The chondrocyte pericellular matrix: a model for hyaluronan-mediated cell-matrix interactions JO - Biochem Soc Trans VL - 27 UR - https://doi.org/10.1042/bst0270142 DO - 10.1042/bst0270142 ID - Knudson1999 ER - TY - JOUR AU - Lark, M. W. AU - Bayne, E. K. AU - Flanagan, J. AU - Harper, C. F. AU - Hoerrner, L. A. AU - Hutchinson, N. I. AU - Singer, I. I. AU - Donatelli, S. A. AU - Weidner, J. R. AU - Williams, H. R. AU - Mumford, R. A. AU - Lohmander, L. S. PY - 1997 DA - 1997// TI - Aggrecan degradation in human cartilage: evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints JO - J Clin Invest VL - 100 UR - https://doi.org/10.1172/JCI119526 DO - 10.1172/JCI119526 ID - Lark1997 ER - TY - JOUR AU - Li, H. AU - Schwartz, N. B. AU - Vertel, B. M. PY - 1993 DA - 1993// TI - cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia JO - J Biol Chem VL - 268 ID - Li1993 ER - TY - JOUR AU - Maehara, H. AU - Suzuki, K. AU - Sasaki, T. AU - Oshita, H. AU - Wada, E. AU - Inoue, T. AU - Shimizu, K. PY - 2007 DA - 2007// TI - G1-G2 aggrecan product that can be generated by m-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage JO - J Biochem (Tokyo) VL - 141 UR - https://doi.org/10.1093/jb/mvm052 DO - 10.1093/jb/mvm052 ID - Maehara2007 ER - TY - JOUR AU - Maroudas, A. AU - Bayliss, M. T. AU - Uchitel-Kaushansky, N. AU - Schneiderman, R. AU - Gilav, E. PY - 1998 DA - 1998// TI - Aggrecan turnover in human articular cartilage: use of aspartic acid racemization as a marker of molecular age JO - Arch Biochem Biophys VL - 350 UR - https://doi.org/10.1006/abbi.1997.0492 DO - 10.1006/abbi.1997.0492 ID - Maroudas1998 ER - TY - JOUR AU - Matsumoto, K. AU - Shionyu, M. AU - Go, M. AU - Shimizu, K. AU - Shinomura, T. AU - Kimata, K. AU - Watanabe, H. PY - 2003 DA - 2003// TI - Distinct interaction of versican/PG-M with hyaluronan and link protein JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M305060200 DO - 10.1074/jbc.M305060200 ID - Matsumoto2003 ER - TY - JOUR AU - McKenna, L. A. AU - Liu, H. AU - Sansom, P. A. AU - Dean, M. F. PY - 1998 DA - 1998// TI - An N-terminal peptide from link protein stimulates proteoglycan biosynthesis in human articular cartilage in vitro JO - Arthritis Rheum VL - 41 UR - https://doi.org/3.0.CO;2-J DO - 3.0.CO;2-J ID - McKenna1998 ER - TY - JOUR AU - Melching, L. I. AU - Roughley, P. J. PY - 1990 DA - 1990// TI - Studies on the interaction of newly secreted proteoglycan subunits with hyaluronate in human articular cartilage JO - Biochim Biophys Acta VL - 1035 UR - https://doi.org/10.1016/0304-4165(90)90168-V DO - 10.1016/0304-4165(90)90168-V ID - Melching1990 ER - TY - JOUR AU - Miller, A. D. AU - Vigdorovich, V. AU - Strong, R. K. AU - Fernandes, R. J. AU - Lerman, M. I. PY - 2006 DA - 2006// TI - Hyal2, where are you? JO - Osteoarthritis Cartilage VL - 14 UR - https://doi.org/10.1016/j.joca.2006.08.004 DO - 10.1016/j.joca.2006.08.004 ID - Miller2006 ER - TY - JOUR AU - Mitchell, N. S. AU - Cruess, R. L. PY - 1977 DA - 1977// TI - Classification of degenerative arthritis JO - Can Med Assoc J VL - 117 ID - Mitchell1977 ER - TY - JOUR AU - Moore, A. C. AU - Burris, D. L. PY - 2014 DA - 2014// TI - An analytical model to predict interstitial lubrication of cartilage in migrating contact areas JO - J Biomech VL - 47 UR - https://doi.org/10.1016/j.jbiomech.2013.09.020 DO - 10.1016/j.jbiomech.2013.09.020 ID - Moore2014 ER - TY - JOUR AU - Moran, C. J. AU - Pascual-Garrido, C. AU - Chubinskaya, S. AU - Potter, H. G. AU - Warren, R. F. AU - Cole, B. J. AU - Rodeo, S. A. PY - 2014 DA - 2014// TI - Restoration of articular cartilage JO - J Bone Joint Surg Am VL - 96 UR - https://doi.org/10.2106/JBJS.L.01329 DO - 10.2106/JBJS.L.01329 ID - Moran2014 ER - TY - JOUR AU - Mort, J. S. AU - Caterson, B. AU - Poole, A. R. AU - Roughley, P. J. PY - 1985 DA - 1985// TI - The origin of human cartilage proteoglycan link-protein heterogeneity and fragmentation during aging JO - Biochem J VL - 232 UR - https://doi.org/10.1042/bj2320805 DO - 10.1042/bj2320805 ID - Mort1985 ER - TY - JOUR AU - Neame, P. J. AU - Barry, F. P. PY - 1993 DA - 1993// TI - The link proteins JO - Experimentia VL - 49 UR - https://doi.org/10.1007/BF01923584 DO - 10.1007/BF01923584 ID - Neame1993 ER - TY - JOUR AU - Nguyen, Q. AU - Liu, J. AU - Roughley, P. J. AU - Mort, J. S. PY - 1991 DA - 1991// TI - Link protein as a monitor in situ of endogenous proteolysis in human articular cartilage JO - Biochem J VL - 278 UR - https://doi.org/10.1042/bj2780143 DO - 10.1042/bj2780143 ID - Nguyen1991 ER - TY - JOUR AU - Oegema, T. R. PY - 1980 DA - 1980// TI - Delayed formation of proteoglycan aggregate structures in human articular cartilage disease states JO - Nature VL - 288 UR - https://doi.org/10.1038/288583a0 DO - 10.1038/288583a0 ID - Oegema1980 ER - TY - JOUR AU - Plaas, A. H. K. AU - Wong-Palms, S. AU - Roughley, P. J. AU - Midura, R. J. AU - Hascall, V. C. PY - 1997 DA - 1997// TI - Chemical and immunological assay of the nonreducing terminal residues of chondroitin sulfate from human aggrecan JO - J Biol Chem VL - 272 UR - https://doi.org/10.1074/jbc.272.33.20603 DO - 10.1074/jbc.272.33.20603 ID - Plaas1997 ER - TY - JOUR AU - Poole, A. R. AU - Ionescu, M. AU - Swan, A. AU - Dieppe, P. A. PY - 1994 DA - 1994// TI - Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan: implications for pathogenesis JO - J Clin Invest VL - 94 UR - https://doi.org/10.1172/JCI117314 DO - 10.1172/JCI117314 ID - Poole1994 ER - TY - JOUR AU - Rawlings, N. D. AU - Barrett, A. J. AU - Bateman, A. PY - 2012 DA - 2012// TI - MEROPS: the database of proteolytic enzymes, their substrates and inhibitors JO - Nucleic Acids Res VL - 40 UR - https://doi.org/10.1093/nar/gkr987 DO - 10.1093/nar/gkr987 ID - Rawlings2012 ER - TY - JOUR AU - Recklies, A. D. AU - White, C. AU - Melching, L. I. AU - Roughley, P. J. PY - 2001 DA - 2001// TI - Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells JO - Biochem J VL - 354 UR - https://doi.org/10.1042/bj3540017 DO - 10.1042/bj3540017 ID - Recklies2001 ER - TY - JOUR AU - Rodriguez, E. AU - Roughley, P. PY - 2006 DA - 2006// TI - Link protein can retard the degradation of hyaluronan in proteoglycan aggregates JO - Osteoarthritis Cartilage VL - 14 UR - https://doi.org/10.1016/j.joca.2006.02.008 DO - 10.1016/j.joca.2006.02.008 ID - Rodriguez2006 ER - TY - JOUR AU - Rodriguez, E. AU - Roland, S. K. AU - Plaas, A. AU - Roughley, P. J. PY - 2006 DA - 2006// TI - The glycosaminoglycan attachment regions of human aggrecan JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M512531200 DO - 10.1074/jbc.M512531200 ID - Rodriguez2006 ER - TY - JOUR AU - Roughley, P. J. AU - Barnett, J. AU - Zuo, F. AU - Mort, J. S. PY - 2003 DA - 2003// TI - Variations in aggrecan structure modulate its susceptibility to aggrecanases JO - Biochem J VL - 375 UR - https://doi.org/10.1042/bj20030609 DO - 10.1042/bj20030609 ID - Roughley2003 ER - TY - JOUR AU - Roughley, P. J. AU - White, R. J. PY - 1980 DA - 1980// TI - Age-related changes in the structure of the proteoglycan subunits from human articular cartilage JO - J Biol Chem VL - 255 ID - Roughley1980 ER - TY - JOUR AU - Roughley, P. J. AU - White, R. J. AU - Glant, T. T. PY - 1987 DA - 1987// TI - The structure and abundance of cartilage proteoglycan during early development of the human fetus JO - Ped Res VL - 22 UR - https://doi.org/10.1203/00006450-198710000-00009 DO - 10.1203/00006450-198710000-00009 ID - Roughley1987 ER - TY - JOUR AU - Roughley, P. J. AU - White, R. J. AU - Poole, A. R. PY - 1985 DA - 1985// TI - Identification of a hyaluronic acid-binding protein that interferes with the preparation of high-buoyant-density proteoglycan aggregates from adult human articular cartilage JO - Biochem J VL - 231 UR - https://doi.org/10.1042/bj2310129 DO - 10.1042/bj2310129 ID - Roughley1985 ER - TY - JOUR AU - Salazar, J. AU - Bello, L. AU - Chavez, M. AU - Anez, R. AU - Rojas, J. AU - Bermudez, V. PY - 2014 DA - 2014// TI - Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism JO - Arthritis VL - ᅟ ID - Salazar2014 ER - TY - JOUR AU - Sandy, J. D. AU - Flannery, C. R. AU - Boynton, R. E. AU - Neame, P. J. PY - 1990 DA - 1990// TI - Isolation and characterization of disulfide-bonded peptides from the three globular domains of aggregating cartilage proteoglycan JO - J Biol Chem VL - 265 ID - Sandy1990 ER - TY - JOUR AU - Sandy, J. D. AU - Flannery, C. R. AU - Neame, P. J. AU - Lohmander, L. S. PY - 1992 DA - 1992// TI - The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain JO - J Clin Invest VL - 89 UR - https://doi.org/10.1172/JCI115742 DO - 10.1172/JCI115742 ID - Sandy1992 ER - TY - JOUR AU - Sandy, J. D. AU - Verscharen, C. PY - 2001 DA - 2001// TI - Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo JO - Biochem J VL - 358 UR - https://doi.org/10.1042/bj3580615 DO - 10.1042/bj3580615 ID - Sandy2001 ER - TY - JOUR AU - Santer, V. AU - White, R. J. AU - Roughley, P. J. PY - 1982 DA - 1982// TI - O-linked oligosaccharides of human articular cartilage proteoglycan JO - Biochim Biophys Acta VL - 716 UR - https://doi.org/10.1016/0304-4165(82)90017-4 DO - 10.1016/0304-4165(82)90017-4 ID - Santer1982 ER - TY - JOUR AU - Shi, S. AU - Mercer, S. AU - Eckert, G. J. AU - Trippel, S. B. PY - 2012 DA - 2012// TI - Regulation of articular chondrocyte aggrecan and collagen gene expression by multiple growth factor gene transfer JO - J Orthop Res VL - 30 UR - https://doi.org/10.1002/jor.22036 DO - 10.1002/jor.22036 ID - Shi2012 ER - TY - JOUR AU - Stern, R. AU - Kogan, G. AU - Jedrzejas, M. J. AU - Soltes, L. PY - 2007 DA - 2007// TI - The many ways to cleave hyaluronan JO - Biotechnol Adv VL - 25 UR - https://doi.org/10.1016/j.biotechadv.2007.07.001 DO - 10.1016/j.biotechadv.2007.07.001 ID - Stern2007 ER - TY - JOUR AU - Struglics, A. AU - Hansson, M. PY - 2012 DA - 2012// TI - MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover JO - Biochem J VL - 446 UR - https://doi.org/10.1042/BJ20120274 DO - 10.1042/BJ20120274 ID - Struglics2012 ER - TY - JOUR AU - Struglics, A. AU - Larsson, S. AU - Pratta, M. A. AU - Kumar, S. AU - Lark, M. W. AU - Lohmander, L. S. PY - 2006 DA - 2006// TI - Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments JO - Osteoarthritis Cartilage VL - 14 UR - https://doi.org/10.1016/j.joca.2005.07.018 DO - 10.1016/j.joca.2005.07.018 ID - Struglics2006 ER - TY - JOUR AU - Sztrolovics, R. AU - Alini, M. AU - Roughley, P. J. AU - Mort, J. S. PY - 1997 DA - 1997// TI - Aggrecan degradation in human intervertebral disc and articular cartilage JO - Biochem J VL - 326 UR - https://doi.org/10.1042/bj3260235 DO - 10.1042/bj3260235 ID - Sztrolovics1997 ER - TY - JOUR AU - Trippel, S. AU - Cucchiarini, M. AU - Madry, H. AU - Shi, S. AU - Wang, C. PY - 2007 DA - 2007// TI - Gene therapy for articular cartilage repair JO - Proc Inst Mech Eng H VL - 221 UR - https://doi.org/10.1243/09544119JEIM237 DO - 10.1243/09544119JEIM237 ID - Trippel2007 ER - TY - JOUR AU - Troeberg, L. AU - Nagase, H. PY - 2012 DA - 2012// TI - Proteases involved in cartilage matrix degradation in osteoarthritis JO - Biochim Biophys Acta VL - 1824 UR - https://doi.org/10.1016/j.bbapap.2011.06.020 DO - 10.1016/j.bbapap.2011.06.020 ID - Troeberg2012 ER - TY - JOUR AU - Valhmu, W. B. AU - Palmer, G. D. AU - Rivers, P. A. AU - Ebera, S. AU - Cheng, J. -. F. AU - Fischer, S. AU - Ratcliffe, A. PY - 1995 DA - 1995// TI - Structure of the human aggrecan gene: exon-intron organization and association with the protein domains JO - Biochem J VL - 309 UR - https://doi.org/10.1042/bj3090535 DO - 10.1042/bj3090535 ID - Valhmu1995 ER - TY - JOUR AU - Verzijl, N. AU - Degroot, J. AU - Bank, R. A. AU - Bayliss, M. T. AU - Bijlsma, J. W. AU - Lafeber, F. P. AU - Maroudas, A. AU - TeKoppele, J. M. PY - 2001 DA - 2001// TI - Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: the use of pentosidine levels as a quantitative measure of protein turnover JO - Matrix Biol VL - 20 UR - https://doi.org/10.1016/S0945-053X(01)00158-5 DO - 10.1016/S0945-053X(01)00158-5 ID - Verzijl2001 ER - TY - JOUR AU - Walcz, E. AU - Deak, F. AU - Erhardt, P. AU - Coulter, S. N. AU - Fülöp, C. AU - Horvath, P. AU - Doege, K. J. AU - Glant, T. T. PY - 1994 DA - 1994// TI - Complete coding sequence, deduced primary structure, chromosomal localization, and structural analysis of murine aggrecan JO - Genomics VL - 22 UR - https://doi.org/10.1006/geno.1994.1396 DO - 10.1006/geno.1994.1396 ID - Walcz1994 ER - TY - JOUR AU - Wang, M. AU - Liu, C. AU - Thormann, E. AU - Dèdinaitè, A. PY - 2013 DA - 2013// TI - Hyaluronan and phospholipid association in biolubrication JO - Biomacromolecules VL - 14 UR - https://doi.org/10.1021/bm400947v DO - 10.1021/bm400947v ID - Wang2013 ER - TY - JOUR AU - Wang, Z. AU - Weitzmann, M. N. AU - Sangadala, S. AU - Hutton, W. C. AU - Yoon, S. T. PY - 2013 DA - 2013// TI - Link protein N-terminal peptide binds to bone morphogenetic protein (BMP) type II receptor and drives matrix protein expression in rabbit intervertebral disc cells JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.451948 DO - 10.1074/jbc.M113.451948 ID - Wang2013 ER - TY - JOUR AU - Watanabe, H. AU - Yamada, Y. AU - Kimata, K. PY - 1998 DA - 1998// TI - Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function JO - J Biochem (Tokyo) VL - 124 UR - https://doi.org/10.1093/oxfordjournals.jbchem.a022166 DO - 10.1093/oxfordjournals.jbchem.a022166 ID - Watanabe1998 ER - TY - JOUR AU - Watanabe, H. AU - Cheung, S. C. AU - Itano, N. AU - Kimata, K. AU - Yamada, Y. PY - 1997 DA - 1997// TI - Identification of hyaluronan-binding domains of aggrecan JO - J Biol Chem VL - 272 UR - https://doi.org/10.1074/jbc.272.44.28057 DO - 10.1074/jbc.272.44.28057 ID - Watanabe1997 ER - TY - JOUR AU - Weigel, P. H. AU - De Angelis, P. L. PY - 2007 DA - 2007// TI - Hyaluronan synthases: a decade-plus of novel glycosyltransferases JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.R700036200 DO - 10.1074/jbc.R700036200 ID - Weigel2007 ER - TY - JOUR AU - Williams, R. AU - Khan, I. M. AU - Richardson, K. AU - Nelson, L. AU - McCarthy, H. E. AU - Analbelsi, T. AU - Singhrao, S. K. AU - Dowthwaite, G. P. AU - Jones, R. E. AU - Baird, D. M. AU - Lewis, H. AU - Roberts, S. AU - Shaw, H. M. AU - Dudhia, J. AU - Fairclough, J. AU - Briggs, T. AU - Archer, C. W. PY - 2010 DA - 2010// TI - Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage JO - PLoS One VL - 5 UR - https://doi.org/10.1371/journal.pone.0013246 DO - 10.1371/journal.pone.0013246 ID - Williams2010 ER - TY - JOUR AU - Zheng, J. AU - Luo, W. AU - Tanzer, M. L. PY - 1998 DA - 1998// TI - Aggrecan synthesis and secretion: a paradigm for molecular and cellular coordination of multiglobular protein folding and intracellular trafficking JO - J Biol Chem VL - 273 UR - https://doi.org/10.1074/jbc.273.21.12999 DO - 10.1074/jbc.273.21.12999 ID - Zheng1998 ER -