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Journal of Experimental Orthopaedics
Fig. 7 | Journal of Experimental Orthopaedics

Fig. 7

From: Diminazene aceturate or losartan ameliorates the functional, radiological and histopathological alterations in knee osteoarthritis rodent model: repurposing of the ACE2/Ang1-7/MasR cascade

Fig. 7

Effect of individual drug treatments on the histomorphic changes of the patellofemoral joint in H&E and safranin O fast green stained sections. a Articular cartilage thickening, b OARSI grade, c synovitis, d fibrosis and e total infrapatellar fat pad (IPF). The total IPF assessment resembles the total score of synovitis and fibrosis. Data are presented as means ± SEM (n = 4). Comparisons among groups were analyzed using one-way ANOVA followed by Tukey post-hoc test for the articular cartilage thickening assessment. Kruskal–Wallis test, followed by Dunn's post-hoc test was used to analyze the OARSI grade and IPF scores. Data are compared at p < 0.05 with CN (*), OA (#), and LOS (-) at p < 0.05. CN; control, OA; MIA induced osteoarthritis, LOS; losartan treated osteoarthritis and DIZE; diminazene treated osteoarthritis

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