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Journal of Experimental Orthopaedics
Fig. 4 | Journal of Experimental Orthopaedics

Fig. 4

From: Diminazene aceturate or losartan ameliorates the functional, radiological and histopathological alterations in knee osteoarthritis rodent model: repurposing of the ACE2/Ang1-7/MasR cascade

Fig. 4

Effect of individual drug treatments on the biochemical parameters. Tissue levels of (a) angiotensin-converting enzyme 1 (ACE1), (b) angiotensin-converting enzyme 2 (ACE2), (c) angiotensin (Ang) 1–7, (d) Ang II, (e) transforming growth factor beta 1 (TGF-β1) and (f) NADPH oxidases 4 (NOX-4). Drugs were administered daily for 21 days. Data are presented as means ± SEM (n = 6). Comparisons among groups were analyzed using one-way ANOVA followed by Tukey post-hoc test. Data are compared at p < 0.05 with CN (*), OA (#) and LOS (-). CN; control, OA; MIA induced osteoarthritis, LOS; losartan treated osteoarthritis and DIZE; diminazene treated osteoarthritis

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