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Journal of Experimental Orthopaedics
Fig. 3 | Journal of Experimental Orthopaedics

Fig. 3

From: Diminazene aceturate or losartan ameliorates the functional, radiological and histopathological alterations in knee osteoarthritis rodent model: repurposing of the ACE2/Ang1-7/MasR cascade

Fig. 3

Effect of individual drug treatments on western blot parameters. Tissue levels of (a) tumor necrosis factor-alpha (TNF-α), (b) matrix metalloproteinases 13 (MMP13) and (c) mas receptor (MasR). The western blot bands are grouped from different gels and presented in (d). Drugs were administered daily for 21 days. Data are presented as means ± SEM (n = 3). Comparisons among groups were analyzed using one-way ANOVA followed by Tukey post-hoc test. Data are compared at p < 0.05 with CN (*), OA (#) and LOS (-). CN; control, OA; MIA induced osteoarthritis, LOS; losartan treated osteoarthritis and DIZE; diminazene treated osteoarthritis

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