Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes

Journal of Experimental Orthopaedics

Table 3 Biomarker Longitudinal Changes ^a

	BL Open Adolescents	P-value	BL Closed Adolescents	P-value	Adults	P-value
CILP-2 [ng/ml]	0.79 (−0.32, 1.9)	0.116	1.8 (−0.72, 4.4)	0.144	1.2 (0.23, 2.1)	0.021*
COMP [U/l]	1.3 (−1.4, 4.1)	0.917	0.13 (−8.5, 8.7)	>0.999	0.44 (−1.4, 2.3)	0.948
sC2C [ng/ml]	−54.3 (−131.4, 22.7)	0.116	−36.3 (−142.6, 70.1)	0.273	43.1 (−14.4, 100.7)	0.17
CPII [ng/ml]	−128.8 (−231.4, −26.2)	0.028*	−57.9 (−253.1, 137.2)	0.273	73.4 (−75.1, 221.8)	0.586
C2C-HUSA [ng/mmol]	−7.8 (−17.8, 2.0)	0.012*	−2.5 (−6.7, 1.6)	0.080	0.1079 (−0.0061, 0.22)	0.033*
CTX-II [ng/mmol]	−11,051.3 (−18,920.3, −3182.2)	0.002*	−2652.8 (−7578.2, 2272.7)	0.080	25.6 (−18.5, 69.9)	0.26

*Statistically significant difference (P < 0.05)
^a BL baseline, BL Open Adolescents adolescents with open growth plates at BL, BL Closed Adolescents adolescents with closed growth plates at BL. Data provided as mean (95% confidence interval)